Insulin Resistance Market Outlook, Trends And Future Opportunities (2023-2030)

Insulin Resistance Market Outlook, Trends And Future Opportunities (2023-2030)

Insulin Resistance Market, By Drug Class (Biguanides, Thiazolidinediones, DPP-4 Inhibitors, SGLT-2 Inhibitors, GLP-1 Receptor Agonists, Others), By Route of Administration (Oral, Injectable, Inhalable), By Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies, Diabetes Clinics/Centers), Region (North America, Europe, Asia Pacific, Latin America, Middle East & Africa) The report offers a comprehensive view of the market from supply as well as demand side to help take informed decisions.

  • Published On: Oct 2023
  • Report ID: IDA50
  • Region: Global
  • Format: PDF/EXCEL

The Insulin Resistance Market is on a trajectory of significant growth, with expectations set for it to reach a substantial US$ 32.8 billion by the year 2030, marking a notable increase from the US$ 23.4 billion recorded in 2023. This growth journey is underscored by a steady Compound Annual Growth Rate (CAGR) of 4.9% during the forecast period from 2023 to 2030.

Insulin resistance, in essence, denotes a condition wherein cells exhibit abnormal responsiveness to the insulin hormone, culminating in excessively high blood sugar levels. The insulin resistance market encompasses both drugs and devices, aimed at treating and managing this condition. Key driving factors include the escalating prevalence of diabetes and the global obesity epidemic.

Insulin resistance is a medical condition characterized by the reduced responsiveness of the body's cells to the hormone insulin, which plays a vital role in regulating blood sugar levels. This resistance results in elevated blood glucose levels, as insulin cannot effectively facilitate glucose uptake by cells. Major contributing factors to insulin resistance encompass obesity, physical inactivity, genetic predisposition, and the natural aging process. Left untreated, insulin resistance can progress to the development of type 2 diabetes. The global insulin resistance market encompasses a spectrum of treatments, including drugs, devices, and supplements, aimed at managing insulin resistance and preventing its progression into diabetes.

The market's intricate segmentation strategy encompasses drug class, route of administration, distribution channels, devices, and end-user demographics. Within the realm of drug class, biguanides, exemplified by metformin, dominate as the largest segment. Metformin's widespread utilization as a first-line medication for Type 2 diabetes, a condition intimately linked with insulin resistance, underscores its prominence. Notably, the recent introduction of oral semaglutide by Novo Nordisk in 2021, targeting improved glycemic control in adult patients with Type 2 diabetes, is expected to invigorate market growth, offering a promising avenue for innovation and enhanced treatment options.

Epidemiology Insights:

  • In the U.S., around 88 million adults aged 18 years or older have prediabetes, indicating the potential for rising prevalence of insulin resistance.
  • Insulin resistance tends to increase with age, and is exacerbated by obesity, physical inactivity, genetic factors and unbalanced diets. These trends are contributing to growth in most developed nations.
  • In 2022, there were approximately 537 million adults aged 20-79 years suffering from diabetes globally according to IDF estimates. 90-95% of these patients have Type 2 diabetes often accompanied by insulin resistance.
  • The increasing diabetic population worldwide presents significant opportunities for treatment and monitoring of insulin resistance.

Market Landscape:

  • There is a need for therapies that can improve insulin sensitivity through novel mechanisms of action rather than simply managing blood glucose levels reactively.
  • Current options include metformin, TZDs, SGLT2 inhibitors, GLP-1 receptor agonists prescribed alone or in combination for glycemic control.
  • Pipeline drugs like AKR-001 by Akero Therapeutics, TTP399 by vTv Therapeutics target underlying insulin resistance through pathways like FGF21 and GLP-1.
  • Non-pharmacological options include physical activity, dietary changes and bariatric surgery in severe cases to reduce insulin resistance.
  • The market has a mix of generics and branded drugs, with some large pharmaceutical companies like Novo Nordisk, Merck, Sanofi and others competing in the space.

Insulin Resistance Market Drivers:

Rising Prevalence of Diabetes and Obesity

The growing prevalence of obesity and diabetes globally is a major factor driving growth in the insulin resistance market. Lifestyle changes, poor dietary habits and reduced physical activity have contributed to rising obesity rates worldwide. Obesity is closely linked to insulin resistance and Type 2 diabetes. According to WHO, worldwide obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults aged 18 years and older were overweight. Of these, over 650 million adults were obese. Diabetes also continues to increase globally. As per IDF estimates, around 537 million adults suffered from diabetes in 2021. This is projected to increase to 643 million by 2030 and 783 million by 2045. The bulk of this diabetic population suffers from Type 2 diabetes often accompanied by underlying insulin resistance. As the patient pool expands, the demand for drugs, devices and supplements to treat insulin resistance is also rising significantly.

Advances in Diabetes Drugs and Technology

The insulin resistance drugs and devices market is driven by constant advances being made in pharmacological interventions and diabetes technology. Pharmaceutical companies are developing novel drugs with improved efficacy to target insulin resistance through unique mechanisms of action. These include gut-derived hormones like GLP-1, FGF21 analogs and others which can lower blood glucose by increasing insulin sensitivity. Device makers are also innovating to provide non-invasive painless blood glucose monitoring, closed loop insulin pumps, smart insulin pens, and integrated digital diabetes management solutions. For instance, big data analytics and AI are being leveraged to gather insights and enable personalized treatment. These advances are improving patient outcomes and helping in the optimal control of insulin resistance.

Increasing Research into Insulin Resistance Pathogenesis

Extensive ongoing research to better understand the molecular mechanisms underlying insulin resistance is supporting the development of targeted and effective therapies. research has identified key defects in insulin signaling pathways and molecules like IRS and GLUT4 that can be selectively targeted. Advances in genomics and biomarker identification have elucidated genetic and epigenetic contributors. Research on gut microbiota-mediated mechanisms also presents possibilities for therapeutic modulation of insulin sensitivity. Such research is enabling drug discovery of novel insulin sensitizers. Government and private funding initiatives to support insulin resistance research also contribute to market growth.

Favorable Reimbursement and Government Policies

Favorable reimbursement scenarios and government policies focused on diabetes prevention and care are driving insulin resistance market growth. Health insurance coverage for diabetes medication, devices and screening tests incentivizes patient adoption. Government-led programs for early screening, diabetes education and awareness especially in developed countries like the US, UK and others promote diagnosis and lower insulin resistance progression. Efforts to encourage weight management through diet and exercise also provide impetus to growth. Tax benefits for expenses related to diabetes treatment are offered in some countries. These policy-level drivers are critical for market expansion.

Key Insights


The market size in 2023

US$ 23.4 Bn

CAGR (2023 - 2030)


The revenue forecast in 2030

US$ 32.8 Bn

Base year for estimation


Historical data


Forecast period


Quantitative units

Revenue in USD Million, and CAGR from 2021 to 2030

Market segments

By Drug Class: Biguanides, Thiazolidinediones, DPP-4 Inhibitors, SGLT-2 Inhibitors, GLP-1 Receptor Agonists, Others

By Route of Administration: Oral, Injectable, Inhalable

By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies, Diabetes Clinics/Centers

Regional scope

North America, Europe, Asia Pacific, Latin America, Middle East, and Africa

Market Drivers

  • Rising prevalence of diabetes and obesity
  • Advances in diabetes drugs and technology
  • Increasing research into insulin resistance pathogenesis
  • Favorable reimbursement and government policies

Market Restraints

  • Lack of symptom awareness and low screening rates
  • High costs of drugs and devices
  • Safety and efficacy concerns with emerging drugs

Competitive Landscape

Novo Nordisk, Eli Lilly, Sanofi, Abbott Laboratories, AstraZeneca, Merck

Insulin Resistance Market Opportunities:

Drug Repurposing and Reformulations

Drug repurposing and novel delivery methods for existing anti-diabetic drugs provides significant opportunities for market growth. For instance, oral formulations are being developed for drugs currently only available as injectables like semaglutide, liraglutide and others. These are long-acting GLP-1 receptor agonists that can improve glycemic control in diabetes by increasing insulin sensitivity. Oral administration improves patient compliance and enables easy self-administration. Reformulation of drugs like metformin with sustained-release profiles also provides advantages. By expanding indications, drug repurposing further widens the addressable patient pool. Biguanides and TZDs commonly prescribed for Type 2 diabetes have applications for treatment of insulin resistance in pre-diabetes as well.

Combination Drugs and Multi-Target Approaches

Insulin resistance pathways are complex with multiple defects involved. This provides the opportunity for combination drugs that can target different mechanisms simultaneously for superior efficacy. For example, GLP-1 receptor agonists are being combined with SGLT2 inhibitors. Combination approaches also reduce side effects of individual drugs. Multi-target drugs designed to act on both insulin resistance and associated metabolic defects like dyslipidemia, inflammation and hypertension also provide wide applicability. Polypharmacy is common in diabetic patients, and fixed-dose combinations enhance patient compliance through reduced pill burden.

Lifestyle and Dietary Interventions

Lifestyle interventions through diet and exercise to reduce obesity and improve insulin sensitivity provide a large opportunity for growth. Programs to promote weight loss, muscle building physical activity and consumption of foods with a low glycemic index can help restore insulin sensitivity. For example, the Mediterranean diet high in unsaturated fats from foods like nuts, fish, olive oil and whole grains has proven benefits. Nutritional supplements like chromium, magnesium, zinc, cinnamon and others also hold potential. Lifestyle changes coupled with pharmacotherapy demonstrate greater efficacy than either approach alone. Leveraging technology like apps, remote monitoring devices and virtual coaching can enhance patient engagement with lifestyle measures.

Direct-to-Consumer Testing and Personalized Medicine

The increasing popularity of direct-to-consumer tests for biomarkers like blood glucose, HbA1c, vitamin deficiencies, genetics, microbiome testing and others provides opportunities for early insulin resistance screening and personalized interventions. Based on individual test results, customized diet, exercise and treatment plans can be devised in collaboration with healthcare providers to improve outcomes. Pharmacogenomic testing also enables tailored drug therapy based on how one’s genetics impacts drug metabolism and response. As consumer interest in preventive personalized health grows, DTC testing and personalized medicine will expand the market.

Insulin Resistance Market Trends:

Integration with Digital Health Solutions

The integration of digital health technologies like mobile apps, wearables, telehealth and analytics software as part of insulin resistance management is a key trend. Digital diabetes management systems enable patients to easily log health data and share with providers for timely interventions. Remote patient monitoring through connected glucometers and CGMs allows real-time glycemic control. Wearable devices can track physical activity, sleep, diet and more to give insights into insulin resistance triggers. With big data analytics, predictive and personalized care becomes feasible. Virtual diabetes clinics and telehealth also improve access and convenience. Software platforms integrate data from devices, EHRs, patients and clinicians to optimize insulin resistance care.

Rising Adoption of CGM Systems

Continuous glucose monitoring systems are seeing rapid adoption among Type 2 diabetic patients to improve glycemic variability and enhance insulin sensitivity. Advantages like 24/7 monitoring without fingerpricks, hypo/hyperglycemia alerts, data integration are driving usage. Interoperable CGMs that communicate with insulin pumps and pens enable automated insulin delivery. New user-friendly features like smaller wearable sensors, mobile connectivity, extended sensor wear (upto 180 days) are attracting consumers. CGM adoption has tripled over 2018-2021 as per a JMIR study. Players like Dexcom, Abbott, Senseonics and Medtronic offer the latest CGM technologies.

Preference for Non-invasive Devices

Patient demand for non-invasive, pain-free devices to monitor blood glucose levels and deliver insulin is rising. This includes technologies like skin patches, optical sensors, ultrasound, electromagnetic sensing and others that do not require fingerpricks or skin punctures. For example, PKvitality’s K’Watch Glucose is a non-invasive continuous monitoring wrist-worn device under development. Other innovations include inhaled insulin, oral insulin and transdermal patches. Non-invasive insulin delivery improves patient compliance. The non-invasive segment is projected to register around 25% CAGR over the next decade owing to its benefits.

Increasing Investor Interest

The insulin resistance market is attracting significant investor interest and funding reflecting its strong growth prospects. Private equity firms and VCs are aggressively investing in emerging startups developing novel drugs, biomarkers and diabetes devices. For instance, venture funding in diabetes tech startups reached approximately $1 billion in Q1-Q3 2021 as per a Close Concerns report, higher than previous years. Active deal activity like licensing agreements and collaborations also continues between pharma majors, startups and academic institutions to advance insulin resistance pipelines. The high unmet need and commercial potential make it an investor favorite.

Insulin Resistance Market Restraints:

Lack of Symptom Awareness Leading to Low Screening Rates

A key factor hampering growth of the insulin resistance market is lack of awareness about its associated symptoms among patients. Insulin resistance is often asymptomatic in the prediabetes stage and remains undiagnosed. Symptoms like fatigue, blindness, infections, slow wound healing are dismissed as benign until irreversible complications emerge. This results in low screening rates despite recommendations for annual blood glucose testing in high risk groups like the obese and elderly. A Healthline survey found only 30% adults get tested annually. Delay in detection leads to uncontrolled disease progression and limits treatment opportunities. Educational initiatives are essential to raise screening adherence.

High Costs of Drugs and Devices

The high costs associated with branded anti-diabetic drugs, insulin, and medical devices like pumps and CGMs makes them unaffordable for many patients. Though biguanides like metformin are economical, newer drugs like SGLT2 inhibitors, GLP-1 receptor agonists, and modern insulin analogs are expensive, and not covered adequately by payers. Most CGMs also do not provide high insurance coverage. Medicare plans offer limited benefits for devices like pumps. Out-of-pocket expenditure deters adoption among lower income groups and the underinsured population. Pricing controls and expanded coverage are needed to improve access.

Safety and Efficacy Concerns with Emerging Drugs

Though novel drug mechanisms hold promise, safety issues and adverse effects observed during trials hinder progress to market. For example, Fibrates for lipid modulation were linked to muscle pain and liver problems. FGF21 analogs in development may increase LDL cholesterol. Fexaramine, a synthetic FXR agonist caused diarrhea and gallstone formation in trials. Frequent product recalls like Medtronic’s in 2022 also foster distrust. Strict regulatory evaluations are required to ensure efficacy and safety. Demonstrating superiority over older generic drugs is also challenging. This slows the launch of emerging therapies.

Recent Developments:


Company Name

In January 2023, FDA approved Rybelsus, an oral semaglutide product by Novo Nordisk for improving glycemic control in children and adolescents aged 10 years and above with Type 2 diabetes. This expanded indication is expected to boost product adoption.

Novo Nordisk

In June 2022, Lilly received FDA approval for Mounjaro, a GLP-1 receptor agonist for treating Type 2 diabetes. Mounjaro has clinically demonstrated superior A1c and weight reductions.

Eli Lilly

In April 2021, Forxiga by AstraZeneca received approval for chronic kidney disease treatment. As kidney problems can result from prolonged insulin resistance, this presents increased applicability.


In September 2022, Senseonics announced FDA clearance of its next generation Eversense 180-day CGM system for monitoring glucose levels in diabetes, the longest-lasting implantable CGM.

Senseonics Holdings

In February 2022, Ypsomed and AstraZeneca partnered to integrate digital therapeutics into self-care diabetes management. This aims to improve patient engagement and outcomes.

Ypsomed, AstraZeneca

In June 2022, Sanofi acquired Origimm Biotechnology, gaining its early-stage immunology pipeline asset ORI-001 for treating insulin resistance disorders.


In January 2022, Abbott acquired Walk Vascular, adding JETi peripheral thrombectomy systems for treating diabetics with severe arterial blockages resulting from insulin resistance.


Regional Dynamics of the Insulin Resistance Market:

The Insulin Resistance Market exhibits distinct regional trends and disparities, shaped by various factors including disease prevalence, healthcare infrastructure, and economic conditions. A closer look at regional insights reveals key growth dynamics.

  • North America: Leading the Way North America takes the pole position as the largest market for Insulin Resistance, commanding a significant market share of 40.5% in 2023. This dominance is attributed to several factors, including the alarmingly high prevalence rates of obesity and diabetes, the presence of major industry players, and favorable reimbursement policies. These elements collectively drive the market's growth in North America, which is expected to maintain its leadership throughout the forecast period.
  • Europe: A Strong Contender Europe secures its place as the second-largest Insulin Resistance market, contributing a substantial market share of 29.7% in 2023. The growth in this region is propelled by a rising geriatric population and escalating obesity rates. As these factors continue to exert influence, the European market for Insulin Resistance treatment is expected to remain robust.
  • Asia Pacific: The Growth Engine The Asia Pacific region emerges as the fastest-growing market for Insulin Resistance, anticipated to achieve an impressive CAGR of over 6.2% during the forecast period. This surge in growth is underpinned by expanding healthcare expenditure, technological advancements, and increasing awareness of insulin resistance and its management. The Asia Pacific region represents a dynamic frontier for market expansion, capturing a substantial market share of 22.3%.
  • Other Regions: Contributing to Global Growth While smaller in market share, Latin America and the Middle East & Africa regions play significant roles in the global Insulin Resistance market. Latin America contributes with a market share of 4.2%, while the Middle East & Africa region accounts for 3.3%. These regions, while facing unique healthcare challenges, are integral contributors to the overall global landscape of Insulin Resistance treatment.

In summary, regional variations in disease prevalence, healthcare infrastructure, and economic conditions significantly shape the dynamics of the Insulin Resistance market. North America and Europe maintain their positions as key players, while the Asia Pacific region stands out as a rapidly evolving growth engine. Additionally, Latin America and the Middle East & Africa continue to make valuable contributions to the global landscape of Insulin Resistance management.

Insulin Resistance Market Segmentation –

  • By Drug Class
    • Biguanides
    • Thiazolidinediones
    • DPP-4 Inhibitors
    • SGLT-2 Inhibitors
    • GLP-1 Receptor Agonists
    • Others
  • By Route of Administration
    • Oral
    • Injectable
    • Inhalable
  • By Distribution Channel
    • Hospital Pharmacies
    • Retail Pharmacies
    • Online Pharmacies
    • Diabetes Clinics/Centers
  • Regions
    • North America
      • U.S.
      • Canada
    • Europe
      • Germany
      • U.K.
      • Spain
      • France
      • Italy
      • Russia
      • Rest of Europe
    • Asia Pacific
      • China
      • India
      • Japan
      • Australia
      • South Korea
      • ASEAN
      • Rest of Asia Pacific
    • Latin America
      • Brazil
      • Argentina
      • Mexico
      • Rest of Latin America
    • Middle East & Africa
      • GCC Countries
      • Israel
      • South Africa
      • North Africa
      • Central Africa
      • Rest of the Middle East

Top companies in the Insulin Resistance Market:

  • Novo Nordisk
  • Sanofi
  • Eli Lilly
  • AstraZeneca
  • Johnson & Johnson
  • Abbott Laboratories
  • Merck
  • GSK
  • Pfizer
  • Novartis
  • Boehringer Ingelheim
  • Takeda
  • Biocon
  • Cipla
  • Sun Pharma

Frequently Asked Questions

The Insulin Resistance Market is valued at USD 23.4 billion in 2023. current market size of the genital herpes industry is estimated at around US$ 5.2 billion in 2023.

Rising prevalence of diabetes and obesity, development of novel drugs and devices, favorable policies, technological integration, improving diagnosis, patient awareness programs.

Stringent regulatory requirements, long product development timelines, pricing pressure, side effects, limited awareness in developing regions.

Biguanides drugs like metformin are the leading segment owing to widespread use as first line of treatment.

Novo Nordisk, Sanofi, Eli Lilly, AstraZeneca, Abbott, Roche, Merck, Medtronic, J&J.

The market is projected to reach USD 32.8 billion by 2030 from USD 23.4 billion in 2023, growing at a CAGR of 4.9% during the forecast period.

Rising prevalence of diabetes and obesity, unhealthy lifestyles, advancing pharmaceutical R&D, favorable reimbursement policies, integration of digital technology.